In this blog post we address a business and human rights issue that emerged from the recent report of Ireland’s Commission of Investigation into Mother and Baby Homes: that of corporate complicity in unlicensed clinical trials carried out upon incarcerated children. We give some background on the report and the environment where human rights abuses took place, then outline elements of Ireland’s idiosyncratic regulatory environment and medical system, before pointing both to the dim prospects facing remedy-seeking victims and the necessity for proactive corporate engagement in dealing with the past.